unlockerassistant.exe is a process related to Unlocker utility. This utility allows you to unlock files when the OS reports the file is being used by an other person or program. Disabling or enabling it is down to user preference.
Non-system processes like unlockerassistant.exe originate from software you installed on your system. Since most applications store data in your system's registry, it is likely that over time your registry suffers fragmentation and accumulates invalid entries which can affect your PC's performance. It is recommended that you check your registry to identify slowdown issues