isuspm.exe is a process that belongs to InstallShield from Macrovision. The process automatically checks for the latest updates online. By removing this process you will not get informed about the latest updates for InstallShield.
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Non-system processes like isuspm.exe originate from software you installed on your system. Since most applications store data in your system's registry, it is likely that over time your registry suffers fragmentation and accumulates invalid entries which can affect your PC's performance. It is recommended that you check your registry to identify slowdown issues