s3hotkey.exe is a process associated with S3 Hotkey from S3 Graphics, Inc.
This software is found on laptops incorporating the S3 Twister integrated graphics card and is used to switch between monitors. Disabling or enabling it is down to user preference.
Non-system processes like s3hotkey.exe originate from software you installed on your system. Since most applications store data in your system's registry, it is likely that your registry has suffered fragmentation and accumulated invalid entries which can affect your PC's performance. It is recommended that you check your registry to identify slowdown issues