CLIStart.exe is a program that may have been installed on your computer when you purchased it. The exact disk location where it should be stored on your computer is also shown below to verfiy it is not spyware, as many spyware programs use similiar names and just locate them elsewhere on your hard drive.
Always check the proper disk location of your programs if you are concerned that they may be spyware or malware. This program is from ATI and its related to your graphics card. It is the Control Center Icon and it will be viewable in your system tray. It is not required to be there so you can remove this from your startup.